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KMID : 0378119890160010204
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Chungnam Medical Journal
1989 Volume.16 No. 1 p.204 ~ p.216
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Effcts of Radiation Exposure and Ionic Contrast Media in Human Lymphocyte Cultures
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Abstract
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Cytogenetic effects of radiation exposure and ionic contrast media were evaluated in peripheral lymphocytes. Accentric chromosome fragments produced in cells by radiation exposure or other agents give rise to micronuclei in daughter cells.
The micronuclei could be counted readily in larger number of cells which provided a sensitive measure of radiation exposure and contrast media induced chromosome aberration. Radiation exposure and contrast media induced microunclei formations in human lymphocytes were counted in vitro and in vivo.
Results were as follows：
1. Micronuclei in lymphocytes were produced by exposure to contrast media and/or radiation.
2. Numbers of micronuclei formation in peripheral lymphocytes after enhanced CT were more increased than inert condition.
3. Lymphocytes of micronuclei formation were increased in number of the plate prepared with contrast media only, but the number of lymphocyte of microniclei formation was not proportional to the concentration of contrast media.
4. The number of lymphocytes of radiation exposure and contrast media induced micronuclei formation was increased than the preparation with contrast media only.
5. The number of lymphocytes of radiation exposure and contrast media induced micronuclei formation in vitro was more increased than enhanced CT in vivo.
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